SD-169 ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®

Leverandør: Merck Millipore Calbiochem


M-Clarity™ quality level = MQ100

506158-10
506158-10EA 3500 NOK
506158-10
SD-169 ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®
SD-169

The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.


General description
A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.


Forpakning: Packaged under inert gas

Formel: C₉H₈N₂O
Lagringstemperatur: Kjøleskap
MDL nummer: MFCD07779486
CAS-nummer: 1670-87-7

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