R18 peptide,Biotin

Leverandør: ENZO LIFE SCIENCES

BMLP2250001
ENZOBMLP2250001EA 3450 NOK
ENZOBMLP2250001
R18 peptide,Biotin
Proteiner

14-3-3 inhibitor


The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments and the N-terminal biotin allows it to be used in assay with streptavidin bound membranes.

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SPESIFIKASJONER

Protein/peptide name R18 Peptide
Environmentally Preferable
Arter
Kilde
Konjugering Biotin
Renhet 95%

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