Human recombinant serpin A1 (from cells)

Leverandør: ProSci Inc.

91-483
PRSI91-483EA 10475 NOK
PRSI91-483
Human recombinant serpin A1 (from cells)
Proteiner

Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.


  • This recombinant protein can be used for biological assays. For research use only.


Fusion-Tag: C-6 His tag

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SPESIFIKASJONER

Protein/peptide name Serpin A1
Environmentally Preferable
Protein synonyms AAT|PI|Serpin A1|Alpha-1-Antitrypsin|SERPINA1|Alpha-1-Antiproteinase|Alpha-1 Protease Inhibitor
Protein/peptide type Recombinant
Arter Human
Kilde Cells
Sekvens Glu25-Lys418
Renhet > 95% as determined by reducing SDS-PAGE
Formulering Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 2mM CaCl2, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Molekylvekt 45.35 kD
Lagringsforhold Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Tag sekvens C-6 His tag
Uttestet applikasjon Bioassay

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