Anti-CD8A Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: 53-6.7]

Leverandør: Tonbo Biosciences
50-0081-U100 50-0081-U500 50-0081-U025
50-0081-U100EA 615 NOK
50-0081-U100 50-0081-U500 50-0081-U025
Anti-CD8A Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: 53-6.7]
Antistoffer
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Type: Primary
Antigen: CD8A (CD8a molecule)
Clonality: monoclonal
Clone: 53-6.7
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2a Kappa
Reactivity: Mouse
Bestill nå

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Les mer About VWR