Du søkte etter: Bioss

Artikkenummer: (BOSSBS-7866R)

Produsent: Bioss

Beskrivelse: This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010].

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-7776R)

Produsent: Bioss

Beskrivelse: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-8555R)

Produsent: Bioss

Beskrivelse: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-7751R)

Produsent: Bioss

Beskrivelse: KIF2B belongs to the kinesin-like protein family. It is a plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. It also has microtubule depolymerization activity.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-7815R)

Produsent: Bioss

Beskrivelse: Required for renal tubular integrity.Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-7818R)

Produsent: Bioss

Beskrivelse: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer a labile 4Fe-4S cluster to target apoproteins.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-7863R)

Produsent: Bioss

Beskrivelse: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-8654R)

Produsent: Bioss

Beskrivelse: Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. The FAM81A gene product has been provisionally designated FAM81A pending further characterization.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-5565R)

Produsent: Bioss

Beskrivelse: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-8671R)

Produsent: Bioss

Beskrivelse: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-9416R)

Produsent: Bioss

Beskrivelse: Tetraspanins are a group of hydrophobic membrane proteins that interact with a wide variety of proteins including intracellular signaling molecules, integrins and membrane receptors. TSPAN7 (tetraspanin 7), also known as MXS1 (membrane component chromosome X surface marker 1) or TM4SF2 (transmembrane 4 superfamily member 2), is a 249 amino acid multi-pass membrane protein belonging to the tetraspanin (TM4SF) family of transmembrane proteins. TSPAN7 is believed to play a role in cell motility and cell proliferation. The gene that encodes TSPAN7 maps to human chromosome X and defects in this gene are a cause of mental retardation X-linked type 58 (MRX58), which is characterized by dramatically below average general intellectual functioning.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-8382R)

Produsent: Bioss

Beskrivelse: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-8380R)

Produsent: Bioss

Beskrivelse: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-4705R)

Produsent: Bioss

Beskrivelse: Anti-MYLK Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-4100R)

Produsent: Bioss

Beskrivelse: Anti-DNM1L Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-4218R)

Produsent: Bioss

Beskrivelse: Anti-SQLE Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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