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Rosiglitazone maleate

Artikkenummer: (ACRO462410010)

Produsent: Thermo Scientific

Beskrivelse: Rosiglitazone maleate

UOM: 1 * 1 g

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N/A Each

Rosiglitazone ≥97% (by HPLC)

Produsent: ENZO LIFE SCIENCES

Beskrivelse: Insulin sensitising agent.

New Product

Beskrivelse: Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions <italic>in vivo</italic>. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC<sub>50</sub> values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active <italic>in vivo</italic> as an antidiabetic agent in the <italic>ob/ob</italic> mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

Rosiglitazone ≥98.0% (by HPLC, titration analysis)

Produsent: TCI

Beskrivelse: Rosiglitazone ≥98.0% (by HPLC, titration analysis)

Rosiglitazone Related Compounds, Reference Standard

Produsent: USP

Beskrivelse: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.