Du søkte etter: ProSci Inc.

Artikkenummer: (PRSI91-859)

Produsent: ProSci Inc.

Beskrivelse: Interleukin-21 receptor is also known as IL-21 receptor, IL-21R, CD360. In humans, it is encoded by the IL21R gene. It belongs to the type I cytokine receptor family. Type 4 subfamily contains 2 fibronectin type-III domains. Interleukin-21 receptor is selectively expressed in lymphoid tissues and highly expressed in thymus and spleen. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells. It also promotes the anti-tumor activity of CD8+ T-cells and NK cells.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI91-470)

Produsent: ProSci Inc.

Beskrivelse: Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA7 is a receptor for members of the ephrin-A family. Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. EPHA7 functions as a repulsive guidance molecule during the targeting of retinal axons to the superior colliculus and of neocortical axons to the thalamus. EPHA7 is expressed at a substantial level in most human lung cancers. The high expression of EPHA7 protein may participate in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma. EPHA7 may involve in smoking related lung carcinogenesis.

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Artikkenummer: (PRSI91-572)

Produsent: ProSci Inc.

Beskrivelse: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI1401-14)

Produsent: ProSci Inc.

Beskrivelse: Heart tissue lysate (14 Days Old) was prepared by homogenisation in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7,4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0,1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin.

UOM: 1 * 0,1 mg

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Artikkenummer: (PRSI91-620)

Produsent: ProSci Inc.

Beskrivelse: vesicle-associated membrane protein-associated protein B/C (VAPB) is presents in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. It can form homodimer, and heterodimer with VAPA. It also interacts with VAMP1, VAMP2, HCV NS5A, NS5B, ZFYVE27 and RMDN3. VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. It is involved in cellular calcium homeostasis regulation.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI7045P)

Produsent: ProSci Inc.

Beskrivelse: KEAP1 peptide is used for blocking the activity of KEAP1 antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI92-720)

Produsent: ProSci Inc.

Beskrivelse: Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signalling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signalling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralisation of IL1B by secreted/soluble receptors.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI6979P)

Produsent: ProSci Inc.

Beskrivelse: Fat-free peptide is used for blocking the activity of Fat-free antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI6423P)

Produsent: ProSci Inc.

Beskrivelse: KCNK13 peptide is used for blocking the activity of KCNK13 antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI3241P)

Produsent: ProSci Inc.

Beskrivelse: TRIM5 delta peptide is used for blocking the activity of the TRIM5 delta antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI91-260)

Produsent: ProSci Inc.

Beskrivelse: Human Zinc Finger MYND Domain-Containing Protein 19 (ZMYND19) is a protein that contains 1 MYND-Type Zinc Finger. ZMYND19 can be expressed by the brain, testis, placenta, heart, liver, skeletal muscle, kidney, and stomach. ZMYND19 interacts with GPR24/MCH-R1. It binds to the C terminus of Melanin-Concentrating Hormone Receptor-1 and the N Termini of alpha-Tubulin. ZMYND19 may be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI91-283)

Produsent: ProSci Inc.

Beskrivelse: Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI4217P)

Produsent: ProSci Inc.

Beskrivelse: Strep-tag II peptide is used for blocking the activity of strep-tag II antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI5681P)

Produsent: ProSci Inc.

Beskrivelse: TMEM184A peptide is used for blocking the activity of TMEM184A antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI4105P)

Produsent: ProSci Inc.

Beskrivelse: Neurotrypsin peptide is used for blocking the activity of Neurotrypsin antibody.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI91-971)

Produsent: ProSci Inc.

Beskrivelse: Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension.

UOM: 1 * 1 Each

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