Du søkte etter: RG-13022

Artikkenummer: (PRSI25-179)

Produsent: ProSci Inc.

Beskrivelse: Members of the RGS (regulator of G protein signaling) family, such as RGS6, modulate G protein function by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.

UOM: 1 * 1 Each

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Produsent: TOSOH Bioscience

Beskrivelse: Tosoh’s LenS3™ Multi-Angle Light-Scattering detector combines high-sensitivity MW and Rg determinations with flexibility and ease of use.

New Product

Artikkenummer: (J64630.MA)

Produsent: Thermo Fisher Scientific

Beskrivelse: A cell-permeable, specific DNA methyltransferases inhibitor.

UOM: 1 * 10 mg

HMS Sertifikater Tilbud

Artikkenummer: (PRSI27-989)

Produsent: ProSci Inc.

Beskrivelse: Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.

UOM: 1 * 1 Each

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Artikkenummer: (ANTIA250042-100)

Produsent: ANTIBODIES.COM

Beskrivelse: Mouse monoclonal [RG/26] antibody to beta III Spectrin for ELISA, WB, IF and IHC-P with samples derived from human, mouse and rat.

UOM: 1 * 1 Each

New Product Tilbud

Artikkenummer: (PRSI56-298)

Produsent: ProSci Inc.

Beskrivelse: This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.

UOM: 1 * 400 µl

New Product Tilbud

Artikkenummer: (BAND279)

Produsent: BANDELIN-ELECTRONIC

Beskrivelse: Ultrasonic bath accessories, Test tube holder, RG 2, stainless steel, for six test tubes upto Ø 25 mm and eight test tubes upto Ø 16 mm

UOM: 1 * 1 Items

Tilbud

Artikkenummer: (PRSI31-069)

Produsent: ProSci Inc.

Beskrivelse: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI29-804)

Produsent: ProSci Inc.

Beskrivelse: RGS8 is a member of the regulator of G protein signaling (RGS) family and is a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI31-075)

Produsent: ProSci Inc.

Beskrivelse: RGS9 is a member of the RGS family of signaling proteins that suppress the activity of G proteins by promoting their deactivation.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI7001)

Produsent: ProSci Inc.

Beskrivelse: RGS22 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI6005)

Produsent: ProSci Inc.

Beskrivelse: AXIN1 Antibody: AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI5209)

Produsent: ProSci Inc.

Beskrivelse: RGS21 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI27-067)

Produsent: ProSci Inc.

Beskrivelse: Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI31-064)

Produsent: ProSci Inc.

Beskrivelse: RGS3 inhibits signal transduction by increasing the GTPASE activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.

UOM: 1 * 1 Each

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Artikkenummer: (PRSI29-805)

Produsent: ProSci Inc.

Beskrivelse: RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

UOM: 1 * 1 Each

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