Du søkte etter: Antistoffer

Artikkenummer: (BOSSBS-2808R-HRP)

Produsent: Bioss

Beskrivelse: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

UOM: 1 * 100 µl

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Artikkenummer: (BOSSBS-2808R-A488)

Produsent: Bioss

Beskrivelse: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

UOM: 1 * 100 µl

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Artikkenummer: (APOSBISN0129-25MG)

Produsent: Apollo Scientific

Beskrivelse: Filgotinib is a selective JAK12 inhibitor with IC50 values of 1028nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively.

UOM: 1 * 25 mg

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Produsent: ENZO LIFE SCIENCES

Beskrivelse: Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

New Product

Artikkenummer: (ABNORAB02863.200UL)

Produsent: Abnova

Beskrivelse: Anti-JAK3 Rabbit Recombinant Antibody [clone: JAK2Y10071008-PB6]

UOM: 1 * 200 µl

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Artikkenummer: (ABNOMAB23565.200UL)

Produsent: Abnova

Beskrivelse: Anti-JAK3 (pTyr980/981) Rabbit Monoclonal Antibody [clone: E10]

UOM: 1 * 200 µl

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Artikkenummer: (ABNOMAB23395.200UL)

Produsent: Abnova

Beskrivelse: Anti-JAK3 (pTyr980/981) Rabbit Monoclonal Antibody [clone: E10]

UOM: 1 * 200 µl

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Artikkenummer: (PRSI13-272)

Produsent: ProSci Inc.

Beskrivelse: Anti-Jak3 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Artikkenummer: (BIRBORB69195-100)

Produsent: Biorbyt

Beskrivelse: Anti-JAK3 Mouse Monoclonal Antibody

UOM: 1 * 100 µl

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 This is a MarketSource item. Additional charges may apply

Artikkenummer: (BIRBORB9100-100)

Produsent: Biorbyt

Beskrivelse: Anti-JAK3 Rabbit Polyclonal Antibody (FITC (Fluorescein))

UOM: 1 * 1 Each

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 This is a MarketSource item. Additional charges may apply

Artikkenummer: (ABNOH00003718-M01A)

Produsent: Abnova

Beskrivelse: Anti-JAK3 Mouse Monoclonal Antibody [clone: 3C2]

UOM: 1 * 200 µl

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Artikkenummer: (ABNOMAB23413.100)

Produsent: Abnova

Beskrivelse: Anti-JAK3 (pTyr980/981) Rabbit Monoclonal Antibody [clone: E10] (APC)

UOM: 1 * 100 AE

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Artikkenummer: (ABNOMAB23568.100)

Produsent: Abnova

Beskrivelse: Anti-JAK3 (pTyr980/981) Rabbit Monoclonal Antibody [clone: E10] (APC)

UOM: 1 * 100 AE

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Artikkenummer: (ANTIA78350-96)

Produsent: ANTIBODIES.COM

Beskrivelse: Human JAK3 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human JAK3 in serum, plasma, tissue homogenates, and other biological fluids.

UOM: 1 * 1 Each

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Artikkenummer: (ANTIA80052-96)

Produsent: ANTIBODIES.COM

Beskrivelse: Rat JAK3 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of rat JAK3 in serum, plasma, tissue homogenates, and other biological fluids.

UOM: 1 * 1 Each

New Product Tilbud

Artikkenummer: (ABNORAB02867.100)

Produsent: Abnova

Beskrivelse: Anti-JAK3 Rabbit Recombinant Antibody [clone: JAK3Y980981-E10] (PE)

UOM: 1 * 100 AE

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